Penicillin cocktail in a rocks glass

Penicillin Recipe

Scotch, lemon, honey and ginger with a smoky float.

Blended Scotch and Islay malt
Base Spirit
~18%
Approx ABV
Medium
Difficulty
5 min
Prep Time
🥂 Rocks glass 🧊 One large cube Smoky, spicy, tart

The Penicillin is a Scotch whisky sour sweetened with honey-ginger syrup and finished with a float of smoky Islay single malt. It is warming, spicy and tart, and it is widely regarded as the most successful new cocktail of the 21st century.

Ingredients

Makes
  • 50 ml Blended Scotch whisky
  • 20 ml Fresh lemon juice
  • 20 ml Honey-ginger syrup See the tips for the syrup
  • 10 ml Islay single malt Scotch Floated on top
  • 1 piece Candied ginger For the garnish

Garnish: Candied ginger

How to Make a Penicillin

  1. Add the blended Scotch, lemon juice and honey-ginger syrup to a shaker.
  2. Fill with ice and shake hard for 12 seconds.
  3. Strain into a rocks glass over one large ice cube.
  4. Pour the Islay whisky gently over the back of a spoon so that it floats on top.
  5. Garnish with a piece of candied ginger.

Tips for a Better Penicillin

  • Honey-ginger syrup: simmer 100g of honey, 100ml of water and a 5cm piece of sliced fresh ginger for 5 minutes. Cool, strain and keep in the fridge for up to two weeks.
  • Do not stir after adding the Islay float. The smoky aroma on top is the signature of the drink.
  • For more ginger heat, muddle 2 slices of fresh ginger in the shaker.

About the Penicillin

Sam Ross, a bartender from Melbourne, Australia, created the Penicillin in 2005 at Milk & Honey in New York. He built it as a variation on the Gold Rush, the bar's sour of bourbon, lemon and honey.

His changes were to use blended Scotch, add fresh ginger to the honey syrup and float a small measure of heavily peated Islay whisky on top, so that the first thing you notice is smoke. The name is a joke about the cold-remedy ingredients: whisky, lemon, honey and ginger.

The drink travelled around the world without any brand behind it and now appears on menus from New York and London to Sydney and Mumbai. The IBA lists it as an official cocktail. It is one of the best introductions to peated Scotch for people who think they dislike smoky whisky.

Penicillin Variations

  • Gold Rush: bourbon, lemon and honey syrup, with no ginger or smoke.
  • Mezcal Penicillin: tequila as the base with a float of mezcal.
  • Hot Penicillin: build it in a mug and top with hot water, like a toddy.
  • Indian Malt Penicillin: a blended Scotch base with a float of peated Indian single malt.
  • Whisky Sour: the simpler original, with lemon and sugar.

Frequently Asked Questions

What is in a Penicillin?

A Penicillin is made with 50ml (1.75 oz) blended Scotch whisky, 20ml (0.75 oz) fresh lemon juice, 20ml (0.75 oz) honey-ginger syrup and 10ml (2 tsp) Islay single malt Scotch. It is served in a rocks glass.

How strong is a Penicillin?

Made to this recipe, a Penicillin is about 18% ABV and contains roughly 19 g of pure alcohol. That is about 1.4 US standard drinks, 1.9 Australian standard drinks or 2.4 UK units. It has around 190 calories per serving.

What Scotch should you use in a Penicillin?

A soft blended Scotch for the base, such as Johnnie Walker Black Label, Chivas Regal 12 or Ballantine's. For the float use a peated Islay single malt such as Laphroaig 10, Ardbeg 10 or Lagavulin 16.

Can you make a Penicillin without Islay whisky?

Yes, but you lose most of the smoke. Use a lightly smoky blend such as Johnnie Walker Black Label or Double Black for the whole drink.

Why is it called a Penicillin?

The name is a joke. Whisky, lemon, honey and ginger are the ingredients of a traditional cold remedy. It contains no medicine.

Who invented the Penicillin cocktail?

The Australian bartender Sam Ross created it in 2005 at Milk & Honey in New York.
Drink responsibly. The legal drinking age in India varies by state, from 18 to 25. Alcohol content shown is an estimate and changes with ice, dilution and the strength of the bottle you use. We do not sell alcohol.

About the Author

Shivam Sharma
Shivam Sharma
I am the founder and editor of The Spirit Atlas. With a deep appreciation for fine spirits, I built this platform to be the most helpful and honest spirits guide for Indian readers — covering everything from Scotch and Indian single malts to rum, gin and tequila, along with prices across every major Indian state. My goal is simple: to make the world of spirits a little more approachable for everyone.
Last updated: October 2026